Thrombophlebitis Migrans and Malignancy

The treatment of Cancer is far from being satisfactory. It cannot be eradicated without the damage of the normal and healthy parts. It is usually destructive to the healthy tissue, and often to the whole individual, excision by surgery or destruction by chemotherapy and radiation, weaken the immune system of the body and often do more harm than good. The treatment of Cancer is either by surgery with wide excision or chemotherapy or both. Both methods of treatment are destructive to the individual with no sure of guarantee of cure. It will be explored in the manuscript, the nature of the tumor and its specific antigens and the response of the body by cellular and humoral antibodies. It is discussed that the antibodies respond by two types of reaction, by destruction or by coating and protection of the cancer cells or by interfering with the antibodies that are specific and toxic. That is to say, that there are types which enhance the growth of the malignant cells and interfere with its destruction by the immune system of the body. Searching for a better method of cure is always the goal of every treating physician and immunotherapy comes in the forefront of the list. It is a safe method of treatment and can be combined with conservative surgical excision, which may be required to decrease the antigen load. Limited surgical excision decreases the antigen load and avoids any damage to the healthy tissue. It also increases the possibility of complete cure when combined with the immunotherapy. Thrombophlebitis migrans, which manifest its self often, in several autoimmune disorders and tissue transplantation, is a sign of the body’s attempt to reject different tissues that carry different antigens. In autoimmune disease, the immune system fights its own tissue that acquire different antigen or undergo mutation of its own cells. It is an important subject that relates some types of thrombosis to certain types of malignancy. The relation is important as it is an immunological reaction that can be very useful and safer weapon for treatment, if not complete cure of cancer. The chemotherapy is a more dangerous treatment, since beside its destruction to the malignant cells, it destroys the normal tissues, and in particular the immune system. The discussion in the manuscript focuses in establishing an immunological link between the cancer and the thrombosis, which in turn start the process of rejection and immunological excision. Thrombosis has an immunological origin, to destroy the malignant cells, or can be made so. The presence of different antigens in the tumor is discussed and the ability of the body to produce specific antibodies to destroy and neutralize each of them is explained. Increasing the gap between the antigen {tumour} and the antibody may be a stronger stimulating force to destroy the cancer. The immune cells manipulated and even tailored to be a potent weapon, and an effective remedy for the treatment or even the cure of the patient from his malignancy. Finally a comparison made by the tumor syngraft and the allograft, which confirm that the allograft rejection is applicable to tumor syngraft. The last few pages are devoted to allograft rejection, and this satisfies the reader that tumor cure by immunotherapy.......